Curse of VitalityCurse of Vitality, for instance, likely wont draw too much ire from the enchanted player
I can think of a few Limited formats in which a Simic deck would have literally zero possible answers to some of the best rares
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3 Blazing Hellhound Blood Cultist Bloodhall Priest Bloodtithe Harvester Body Dropper Boggart Cursecrafter Boltwing Marauder Brawl-Bash Ogre Bullseye, Death Dealer Carnage Gladiator Carnage, Crimson Chaos Carnival Hellsteed Chainer, Nightmare Adept Chaos Spewer Chaos, the Endless Charforger Cindering Cutthroat Coalstoke Gearhulk Crash, Reckless Endrider Cruel Administrator Cryptborn Horror Cult Guildmage Cultbrand Cinder Deathbringer Thoctar Deepfire Elemental Defiler of Souls Demigod of Revenge Desecrex, Gift of Servitude Dire Fleet Captain Dire Fleet Neckbreaker Dire Fleet Warmonger Dragonlord Kolaghan Dread Slag Dreadhorde Butcher Dust Stalker Eclipsed Boggart Elite Headhunter Emberstrike Duo Exava, Rakdos Blood Witch Falkenrath Aristocrat Far Fortune, End Boss Fireblade Artist Fireglass Mentor Flayer Drone Florian, Voldaren Scion Footlight Fiend Forerunner of Slaughter Forge Boss Fulminator Mage Garland, Knight of Cornelia Garna, Bloodfist of Keld Garna, the Bloodflame Gastal Thrillseeker Gev, Scaled Scorch Ghostflame Sliver Glistening Goremonger Gobhobbler Rats Goblin Deathraiders Goblin Outlander

Creatures like Isshin, Two Heavens as One, Krenko, Tin Street Kingpin, or Karlach, Fury of Avernus can enter the battlefield and attack right away