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CAS Number: 2448414-54-6
InChi: InChI=1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15
Formula: C40H56N6O2
InChiKey: DZHKYOWYCVBDPW-UHFFFAOYSA-N
BC-LI-0186 degrader 1 CAS Number: 2448414-54-6BC LI 0186 is a potent and selective inhibitor of Leucyl tRNA synthetase (LRS; LeuRS) and Ras related GTP binding protein D (RagD) interaction (IC50=46. 11 nM). BC LI 0186 competitively binds to the RagD interacting site of LRS (Kd=42. 1 nM) and has on effects on LRS Vps34, LRS EPRS, RagB RagD association, mTORC1 complex formation or the activities of 12 kinases. BC LI 0186 can effectively suppress the activity of cancer associated MTOR mutants and
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