Danoprevir 2-yl)ethane-1 2-diamine hydrochloride At concentrations of 4×MIC and

At concentrations of 4×MIC and 8×MIC

Solubility: DMSO 40 mg/mL (83

Molecular Weight: 289

Formula: C20H19ClN6O2

Danoprevir 2-yl)ethane-1 2-diamine hydrochloride At concentrations of 4×MIC andDanoprevir, also known as ITMN 191 and RG 7227, is under development by InterMune Inc and Roche Holding AG, is a promising, potent NS3 4A protease inhibitor for the oral treatment of HCV infection. Preclinical data demonstrated that danoprevir binds with high affinity and dissociates slowly from the HCV NS3 protease, allowing high liver drug exposure with only modest plasma drug exposure. A phase Ib, 'IFN free' clinical trial demonstrated that