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26)/t18-/m0/s1
U2OS cells) reduces the Dox-induced p53K382ac
Smiles: CC[C@H](C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](CC=C(C)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)C=CC=C4CO[C@@H]5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)C=C[C@@H]1C |c:12
Drug Metabol Drug Interact
Dihydrocoumarin (Hydrocoumarin) Catalog No.:M22011-C 26)/t18-/m0/s1Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 M and 295 M, respectively. Dihydrocoumarin induces a concentration dependent inhibition of SIRT1 (IC50 of 208 M) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (855. 8 and 7313. 7% activity at 1. 6 M and 8 M,
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