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24-120 hours) shows cytotoxicity and induction of apoptosis in vitro
Lotamilast is currently in phase 2 development for patients with mild-to-moderate atopic dermatitis
InChi: InChI=1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8
BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1
CM10 10400 24-120 hours) shows cytotoxicity andCM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti cancer activity. Product information CAS Number: 692269 09 3 Molecular Weight: 321. 42 Formula: C20H23N3O Chemical Name: 2 (prop 2 en 1 yl) 6 {[(1 propyl 1H 1,3 benzodiazol 2
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