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If an effect instructs you to sacrifice a creature, and you control any creatures other than the ones you gained control of with Call for Aid this turn, you must sacrifice one of them

This enchantment can kill up a variety of threats over four turns, but at the high cost of 6 cmc and each one is randomly selected, so it's not a good answer if you need a specific threat taken care of immediately

Marvel Cosmic Invasion : Rocket Racoon's Cosmic Grenade ability has him throw a bomb that explodes with a random effect- it may simply deal damage, cause a glue bomb that slows enemies, inflict Cosmic damage over time, or there's a very very low chance of getting a Nuclear Grenade that causes massive damage to all enemies on screen

Fierce Guardianship is widely regarded as one of the best blue cards MTG players can use to create a safety net