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2ClH/c1-37(2)29-15-7-6-14-28(29)32(39)35-19-18-34-26-12-9-13-27(22-26)36-44(41
and new-generation selective ROS1/NTRK inhibitor
CH4O3S/c1-24(13-11-17-9-10-18-12-14-26-23(18)15-17)16-19-5-3-7-21-20(19)6-4-8-22(21)25-2
Sergio O Angel
MJ33 (lithium salt) glanin 2ClH/c1-37(2)29-15-7-6-14-28(29)32(39)35-19-18-34-26-12-9-13-27(22-26)36-44(41MJ33 is an inhibitor of the acidic, calcium independent (ai)PLA2 activity of Prdx6. Peroxiredoxin 6 (Prdx6), a bifunctional enzyme, has both non selenium glutathione peroxidase and phospholipase A2 (PLA2) activities. The PLA2 activity of Prdx6 is calcium independent, functions optimally in acidic conditions, and facilitates the intracellular processing of surfactant lipids, such as dipalmitoylphosphatidylcholine. In vitro: MJ33 was found to be
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